PUBLICATIONS
1. Dorigatti AO, Riordan R, Yu Z, Ross G, Wang R, Reynolds-Lallement N, Magnusson K, Galvan V, Perez VI. "Brain cellular senescence in mouse models of Alzheimer's disease." (2022) Geroscience. doi: 10.1007/s11357-022-00531-5.
2. Strong R, Miller RA, Cheng CJ, Nelson JF, Gelfond J, Allani SK, Diaz V, Dorigatti AO, Dorigatti J, Fernandez E, Galecki A, Ginsburg B, Hamilton KL, Javors MA, Kornfeld K, Kaeberlein M, Kumar S, Lombard DB, Lopez-Cruzan M, Miller BF, Rabinovitch P, Reifsnyder P, Rosenthal NA, Bogue MA, Salmon AB, Suh Y, Verdin E, Weissbach H, Newman J, Maccchiarini F, Harrison DE. "Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice." (2022). Aging Cell. doi: 10.1111/acel.13724.
3. Hussong S.A., Banh, A.Q., Van Skike, C.E., Dorigatti, A.O., Hernandez, S.F., Hart, M.J., Gaczynska, M., Osmulski, P.A., McAllen, S.A., Dineley, K.T., Ungvari, Z., Pérez, V.I., Kayed, R., and Galvan, V. “Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in tauopathy.” (2023). Nat Commun. doi: 10.1038/s41467-023-37840-y.
4. Dorigatti A.O.*, Hussong S.A.*, Hernandez S.F., Sills A.M., Salmon A., Galvan V. "Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: A non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging." (2021). GeroScience. Geroscience. doi: 10.1007/s11357-020-00284-z.*denotes equal contribution.
5. Van Skike, C. E.*, Jahrling, J.B.*, Olson, A.B., Sayre, N.L., Hussong, S.A., Ungvari,Z.I., Lechleiter, J.D., Galvan, V. (2017). "Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment." Am J Physiol Heart Circ Physiol. *denotes equal contribution **Received the American Physiological Society APSselect Award Feb. 2018.
Technical Acknowledgement. Schmidt, K., & Loeb Belinsky, K. (2013). Voices in the dark: Predation risk by owls influences dusk singing in a diurnal passerine. Behavioral Ecology and Sociobiology, 67(11), 1837-1843.
PUBLICATIONS IN PREPARATION FOR SUBMISSION
1. Dorigatti, A.O., Riordan R., Yu, Z., Ross G., Wang R., Galvan V., Perez V. “Characterizing Cellular Senescence in Mouse Models of Alzheimer’s Disease” In preparation for submission
2. Dorigatti, A.O., C.E. Van Skike, V. Galvan. “Pathogenic tau in cerebrovascular dysfunction in Alzheimer’s disease.” Invited review. Front Aging Neurosci. In preparation for submission.
3. Dorigatti, A.O., Cirrito, J., V. Galvan. “mTOR attenuation promotes amyloid beta clearance through LRP1 and PICALM.” J Cereb Blood F Met. In preparation for submission.
4. Dorigatti, A.O., Hernandez, S.F., Hussong, S.A., Kayed, R., Galvan, V. “Tau-induced astrocyte senescence as a driver of neuronal dysfunction in Alzheimer’s disease” In preparation for submission.
PUBLISHED ABSTRACTS
1. Olson, A.B., Hussong,S.A., Sills, A., Kayed, R., Galvan, V. Tau-induced astrocyte senescence: A novel mechanism for neural dysfunction in Alzheimer’s disease. Ladiges, W., Ikeno, Y., Wang, L. et al. Resilience in aging and age-related disease. Abstracts from the 2019 Barshop Conference on Aging[J]. Aging Pathobiology and Therapeutics, 2020, 2(1): 01-13.
2. Banh, A., Hussong, S.A., Van Skike, C., Olson, A.B., Hernandez, S.F., Kayed, R., Galvan, V. Tau-induced endothelial cell impairment as a driver of microvascular dysfunction in Alzheimer’s disease. Ladiges, W., Ikeno, Y., Wang, L. et al. Resilience in aging and age-related disease. Abstracts from the 2019 Barshop Conference on Aging[J]. Aging Pathobiology and Therapeutics, 2020, 2(1): 01-13.
3. Olson, A.B., Hussong,S.A., Kayed, R., Galvan, V. Tau-induced astrocyte senescence: a novel mechanism for neuronal dysfunction in alzheimer’s disease, Innovation in Aging, Volume 3, Issue Supplement_1, November 2019, Pages S91–S92, https://doi.org/10.1093/geroni/igz038.348
4. Hussong, S.A., Van Skike, C.E., Olson, A.B., Hart, M.J., Hernandez, S.F., Banh, A., McAllen, S., Kayed, R. and Galvan, V. (2019), P4‐148: Propagation of soluble tau aggregates in brain microvascular endothelial cells promotes cellular senescence/sasp and blocks enos activation. Alzheimer's & Dementia, 15: P1331-P1331. doi:10.1016/j.jalz.2019.06.3809
5. Olson, A.B, Hussong, S.A., Kayed, R., Galvan, V. Tau-induced astrocyte senescence as a driver of neuronal dysfunction in Alzheimer’s disease. Ladiges W. Barshop Symposium on Aging 2018 Abstracts. Pathobiol Aging Age Relat Dis. 2019;9(Suppl 1):1591258. Published 2019 Mar 19. doi:10.1080/20010001.2019.1591258
6. Van Skike, C.E., Hussong, S.A., Olson, A.B., Hernandez, S.F., Banh, A., DeRosa, N. and Galvan, V. (2018), P4‐063: Neurovascular coupling deficits arise prior to cognitive dysfunction in a mouse model of alzheimer's disease. Alzheimer's & Dementia, 14: P1456-P1457. doi:10.1016/j.jalz.2018.06.2466
7. Olson, A.B, Hussong, S.A., Galvan, V. Tau-induced astrocyte senescence as a driver of neuronal dysfunction in Alzheimer’s disease. Selected Abstracts from the American Aging Association 47th Annual Meeting “Improving Resilience to Delay Aging” Philadelphia, 2018. GeroScience 40, 405–418 (2018). https://doi.org/10.1007/s11357-018-0041-z
8. Van Skike, C.E., Jahrling, J.B., Olson, A.B., Sayre, N.L., Hussong, S.A., Ungvari, Z.I., Lechleiter, J.D., Galvan, V. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment. American Journal of Physiology-Heart and Circulatory Physiology 2018 314:4, H693-H703
9. Olson, A.B, Hussong, S.A., Jarhling, J.B., Galvan, V. mTOR Regulates PICALM in brain vascular cells. Ladiges W. Barshop Symposium on Aging 2017 Abstracts. Pathobiol Aging Age Relat Dis. 2018;8(1):1444939. Published 2018 Mar 7. doi:10.1080/20010001.2018.1444939
10. Hussong, S.A., Olson, A.B, Hart, M.J, Kayed, R., Galvan, V. Prion-like properties of tau oligomers trigger brain vascular endothelial cell dysfunction. Ladiges W. Barshop Symposium on Aging 2017 Abstracts. Pathobiol Aging Age Relat Dis. 2018;8(1):1444939. Published 2018 Mar 7. doi:10.1080/20010001.2018.1444939
11. Olson, A.B., Jarhling, J.B., Hussong, S.A., Galvan, V. The effect of rapamycin on LRP1 transcytosis of Aβ. Promoting healthy aging: intervening with diet, drugs, or exercise. Pathobiology of Aging & Age- Related Diseases. 2016 ;6:34153. DOI: 10.3402/pba.v6.34153.
12. Jarhling, J.B., Sayre, N., Olson, A.B., Galvan, V. Attenuation of mTOR with rapamycin restores blood–brain barrier integrity and function in aging disease models. Promoting healthy aging: intervening with diet, drugs, or exercise. Pathobiology of Aging & Age- Related Diseases. 2016 ;6:34153. DOI: 10.3402/pba.v6.34153.
ORAL PRESENTATIONS
Dorigatti, A.O., Hussong, S.A., Kayed, R., Galvan, V. Astrocyte senescence induced by pathogenic tau transmission is negated by senolytics in a model of Alzheimer’s disease.
1. Barshop Symposium on Aging Graduate Research Update, Virtual, October 14, 2020.
Dorigatti, A.O. Disease-associated astrocytes in Alzheimer’s disease and aging.
2. Biology of Aging Journal Club, TX, October 2, 2020.
Dorigatti, A.O., Hussong, S.A., Kayed, R., Galvan, V. Tau drives neuronal dysfunction in Alzheimer's disease through astrocyte senescence.
3. Mikiten Graduate Research Symposium 3 Minute Thesis, Virtual, September 25, 2020.
Dorigatti, A.O. Fisetin is a senotherapeutic that extends health and lifespan.
4. Biology of Aging Journal Club, TX, February 8, 2020.
Dorigatti, A.O., Hussong, S.A., Kayed, R., Galvan, V. Tau-induced astrocyte senescence: A novel mechanism for neuronal dysfunction in Alzheimer’s disease.
5. Invited Speaker American Aging Association Annual Meeting, Virtual, June 18, 2020.
6. Texas Research Park Seminar. San Antonio, TX, May 2, 2018.
Olson, A.B., Hussong, S.A., Galvan, V. Cellular Senescence in Alzheimer’s disease.
7. UTHSCSA Student Recruitment, San Antonio, TX, January 23, 2020.
8. UTHSCSA Student Recruitment, San Antonio, TX, February 23, 2018.
9. UTHSCSA Student Recruitment, San Antonio, TX, January 26, 2018.
Olson A.B. Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
10. Biology of Aging Journal Club, San Antonio, TX, October 12, 2017.
Olson, A.B., Hussong. S.A., Kayed, R., Galvan, V. Tau-induced astrocyte senescence: A novel mechanism for neuronal dysfunction in Alzheimer’s disease.
11. Brown University, Providence, RI, November 11, 2019.
12. Barshop Institute for Longevity and Aging Studies Seminar Series, San Antonio, TX October 30, 2019.
13. 2019 Barshop Symposium on Aging Graduate Student Research Updates, Bandera, TX, October 10, 2019.
14. 1st Place Data Blitz Speaker Award. American Aging Association Annual Meeting, Burlingame, CA, May 31, 2019.
Olson, A.B., Hussong, S.A., Kayed, R., Galvan, V. Tau-induced astrocyte senescence as a driver of neuronal dysfunction in Alzheimer’s disease.
15. Invited Oral Presentation (Poster Blitz). South Texas Alzheimer’s Conference, San Antonio, TX, February 25, 2019.
Olson A.B. Porphyrominas gingivalis in Alzheimer’s disease brains: evidence for disease causation with small- molecule inhibitors.
16. Biology of Aging Journal Club, San Antonio, TX, February 15, 2019.
Olson, A.B., Hussong S.A., Kayed, R., Galvan, V. Mechanisms linking tau-induced astrocyte senescence to neurodegeneration.
17. 2018 Barshop Symposium on Aging Graduate Student Research Updates, Bandera, TX, October 18, 2018.
Olson A.B. Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson’s disease.
18. Biology of Aging Journal Club, San Antonio, TX, April 6, 2018.
Olson, A.B., Hussong ,S.A., Galvan, V. Tau-induced astrocyte senescence: A novel mechanism of Alzheimer's disease.
19. Invited Oral Presentation. Physiology Graduate Research Symposium. San Antonio, TX, April 20, 2018.
Olson A.B. APOE4 Markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
20. Biology of Aging Journal Club, San Antonio, TX, November 10, 2017.
Olson A.B., Hussong, S.A., Galvan, V. Oligomeric tau in AD brain vasculature.
21. 2017 Barshop Symposium on Aging Graduate Student Research Updates, Bandera, TX, October 12, 2017.
Olson A.B., Hussong, S.A., Galvan, V. Prion-like toxicity of tau oligomers and related cellular senescence in AD brain vasculature.
22. Texas Research Park Seminar, San Antonio, TX, October 5, 2017.
Olson A.B. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.
23. Biology of Aging Journal Club, San Antonio, TX, December 10, 2016.
POSTER PRESENTATIONS
Dorigatti, A.O., Hussong, S.A., Kayed, R., Galvan, V. Senolytic therapy ameliorates tau-induced astrocyte senescence in Alzheimer’s disease model.
1. Annual Medicine Research Day, UTHSCSA, Virtual, Oct. 13, 2020.
2. South Texas Alzheimer’s Conference, San Antonio, TX, February 23-26, 2020.
Dorigatti, A.O., Hernandez, S.F., Hussong, S.A., Kayed, R., Galvan, V. Astrocyte senescence induced by pathogenic tau transmission is negated by senolytics in a model of Alzheimer’s disease.
3. American Aging Association Annual Meeting, Virtual, June 17-19, 2020.
Dorigatti, A.O., Hussong, S.A., Kayed, R., Galvan, V. Tau-induced astrocyte senescence: A novel mechanism for neuronal dysfunction in Alzheimer’s disease.
4. Poster Award. Texas Alzheimer’s Research and Care Consortium, Austin, TX, January 30, 2020.
5. Gerontological Society of America Annual Meeting, Austin, TX November 13, 2019.
6. 2019 Barshop Symposium on Aging, Bandera, TX October 11, 2019.
7. Travel Award. American Aging Association Annual Meeting, Burlingame, CA, June 1, 2019.
8. Cellular and Integrative Physiology Research Day, San Antonio, TX, May 10, 2019.
9. Travel Award and Poster Award. Oklahoma Nathan Shock Geroscience Symposium, Oklahoma City, OK, April 24, 2019.
Olson, A.B., Hussong, S.A., Kayed, R., Galvan, V. Tau-induced astrocyte senescence as a driver of neuroinflammation and neuronal dysfunction in Alzheimer’s disease.
10. Travel Award. Brain and Brain Pet: International Symposium on Cerebral Blood Flow, Metabolism and Function, Yokohama, Japan, July 4-7, 2019.
11. UTHSCSA Student Recruitment, San Antonio, TX, January 25, 2019.
12. American Aging Association Annual Meeting, Philadelphia, PA, June 30, 2018.
Olson, A.B., Hussong, S.A., Kayed, R., Galvan, V. Tau-induced astrocyte senescence as a driver of neuronal dysfunction in Alzheimer’s disease.
13. Poster Award. South Texas Alzheimer’s Conference, San Antonio, TX, February 25, 2019.
Olson, A.B., Hussong, S.A., Kayed, R., Galvan, V. Mechanisms linking tau-induced astrocyte senescence to neurodegeneration.
14. 2018 Barshop Symposium on Aging, Bandera, TX October 19, 2018.
Olson, A.B., Hussong, S.A., Kayed, R., Galvan, V. Tau-induced astrocyte senescence as a driver of Alzheimer’s disease.
15. Biology of Aging Student Day, San Antonio, TX, May 11, 2018.
16. Center for Biomedical Research Retreat, San Antonio, TX, May 4, 2018.
17. IIMS/CTSA 9th Annual Frontiers in Translational Science Research Day, San Antonio, TX, March 2, 2018.
18. Physiology Graduate Research Symposium. San Antonio, TX, April 20, 2018.
Olson, A.B., Jahrling, J.B., Hussong, S.A., Galvan, V. mTOR Regulates PICALM in Brain Vascular Cells.
19. 2017 Barshop Symposium on Aging, Bandera, TX October 13, 2017.
20. Poster Award, Edward J. Masoro Barshop Student Day, Barshop Institute for Longevity and Aging Studies, San Antonio, April 14, 2017.
21. Frontiers of Translational Science Research Day, University of Texas Health Science Center at San Antonio, San Antonio, Texas April 12, 2017.
22. Cellular and Integrative Physiology Symposium, Hilton San Antonio Hill Country Hotel, San Antonio, Texas April 7, 2017.
23. Galveston Symposium on Alzheimer’s Disease and Related Disorders, Galveston Island Convention Center, Galveston, Texas March 22, 2017.
Olson, A.B., Jahrling, J.B., Galvan, V. The Effect of Rapamycin on LRP1 Transcytosis of Aβ.
24. 2016 Barshop Symposium on Aging, Bandera, TX October 14, 2016.
25. 2016 Annual American Aging Association Meeting, Bell Harbor Convention Center Seattle, Washington June 3-4, 2016.
26. Physiology Graduate Student Symposium, University of Texas Health Science Center at San Antonio, San Antonio, May 27, 2016.
27. Edward J. Masoro Barshop Student Day, Barshop Institute for Longevity and Aging Studies, San Antonio, May 13, 2016.
28. Center of Biomedical Neuroscience Retreat, Greehey Children’s Cancer Research Institute, University of Texas Health Science Center, May 6, 2016.